5-methylisoxazole-4-sulfonyl chloride

5-methylisoxazole-4-sulfonyl chloride - Names and Identifiers

Name	5-methylisoxazole-4-sulfonyl chloride
Synonyms	5-Methylisoxazole-4-sulfonylchloride 5-METHYL-4-ISOXAZOLESULFONYL CHLORIDE 4-(Chlorosulphonyl)-5-methylisoxazole 5-methylisoxazole-4-sulfonyl chloride 5-Methylisoxazole-4-sulphonyl chloride 5-METHYL-4-ISOXAZOLESULPHONYL CHLORIDE 4-Isoxazolesulfonyl chloride, 5-Methyl- 4-isoxazolesulfonyl chloride, 5-methyl- 5-Methyl-1,2-oxazole-4-sulfonyl chloride 4-Isoxazolesulfonylchloride,5-methyl-(9CI)
CAS	321309-26-6
InChI	InChI=1/C4H4ClNO3S/c1-3-4(2-6-9-3)10(5,7)8/h2H,1H3

5-methylisoxazole-4-sulfonyl chloride - Physico-chemical Properties

Molecular Formula	C4H4ClNO3S
Molar Mass	181.6
Density	1.534±0.06 g/cm3(Predicted)
Boling Point	56-58°C 0,7mm
Flash Point	136.248°C
Vapor Presure	0.002mmHg at 25°C
pKa	-7.68±0.50(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.508

5-methylisoxazole-4-sulfonyl chloride - Risk and Safety

Risk Codes	R34 - Causes burns R36 - Irritating to the eyes
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
UN IDs	3261
Hazard Note	Corrosive
Hazard Class	8
Packing Group	Ⅲ

5-methylisoxazole-4-sulfonyl chloride - Introduction

It is an organic compound with the chemical formula C4H4ClNO3S. The following is a description of its nature, use, formulation and safety information:

Nature:
is a solid compound, colorless to yellowish crystals. It is stable at room temperature and has a strong smelly acid smell. It has a melting point of about 80-84 degrees Celsius and a boiling point of 340 degrees Celsius. The compound is insoluble in water, but soluble in polar organic solvents.

Use:
chloride is an important intermediate in organic synthesis. It is commonly used in the synthesis of drugs, pesticides and other biologically active compounds. The compounds can be used as condensation reagents and substitution reagents to participate in organic reactions such as esterification, deetherification, olefination, nucleophilic substitution, etc. It can also be used in the synthesis of antibiotics, pesticides and other biologically active compounds.

Method:
The preparation of chloride is usually obtained by reacting p-methylisoxazole (5-methylisoxazole) with sulfonyl chloride (sulfonyl chloride). The reaction is carried out under anhydrous and anaerobic conditions, typically in an organic solvent such as dichloromethane or trichloromethane.

Safety Information:
chloride is an organic compound that is irritating and corrosive. Appropriate safety precautions should be taken during use or handling, including wearing protective glasses, gloves and protective clothing. Avoid inhaling its vapors or touching the skin. In case of inadvertent inhalation or contact, wash the affected area immediately and seek medical help. At the same time, the compound should be stored in a closed container, away from fire and oxidizing agents.

Last Update：2024-04-09 21:11:58